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. 2021 Jul 23;11:715593. doi: 10.3389/fonc.2021.715593

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Copyright © 2021 Yang, Chen, Zhang, Xiong, Wang, Fang, Li, Fei and Gong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ME2 promotes lipogenesis reprogramming in glioma cells. (A) Gene expression heat maps showing expression of ME2, ACLY, and ACSS2 in different gliomas. (B) Localization of SREBP-1 in U251MG cells observed by immunofluorescence staining. (C, D) Relative changes in citrate and pyruvate concentration (C) in SW1783 and U251MG cells and in (D) LN229 and U87MG cells transfected with various plasmids (*P < 0.05). (E, F) Changes in expression of proteins including p-AMPK, AMPK, pro-SREBP-1, M-SREBP-1, ACLY, and ACSS2 in (E) SW1783 and U251MG cells and in (F) U87MG and LN229 cells transfected with various plasmids. (G) Mechanistic diagram of the role of ME2 in GBM.