Fig. 1. On-bead CuAAC cyclization of a linear peptide yields peptide 1, predominantly in monomer form. (A) Structure of peptide monomer (M). (B) Structure of peptide dimer (D). (C) Analytical reverse phase HPLC trace of cyclized peptide 1 cleaved from resin shows M is formed as major product. Absorbance trace at 280 nm is shown.
