Cyclization of pentameric peptides with variable 3rd residue from N-terminal.
Peptide | Cyclic peptide | Linear peptide precursor | Monomer : dimer |
---|---|---|---|
15 | (TYT-Tz4)cy | Fmoc-Pra-TYT-Az4 | 1.90 : 1 |
21 | (TVT-Tz4)cy | Fmoc-Pra-TVT-Az4 | 3.68 : 1 |
22 | (TFT-Tz4)cy | Fmoc-Pra-TFT-Az4 | 2.82 : 1 |
23 | (TWT-Tz4)cy | Fmoc-Pra-TWT-Az4 | 2.90 : 1 |