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. 2021 Jan 27;11(8):4842–4852. doi: 10.1039/d0ra07491h

Cyclization of pentameric peptides with variable 3rd residue from N-terminal.

Peptide Cyclic peptide Linear peptide precursor Monomer : dimer
15 (TYT-Tz4)cy Fmoc-Pra-TYT-Az4 1.90 : 1
21 (TVT-Tz4)cy Fmoc-Pra-TVT-Az4 3.68 : 1
22 (TFT-Tz4)cy Fmoc-Pra-TFT-Az4 2.82 : 1
23 (TWT-Tz4)cy Fmoc-Pra-TWT-Az4 2.90 : 1