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. 2021 Jan 27;11(8):4842–4852. doi: 10.1039/d0ra07491h

Cyclization of pentameric peptides with different amino acids in the 4th residue from N-terminal.

Peptide number Cyclic peptide sequence Linear peptide precursor Monomer : dimer
17 (TTY-Tz4)cy Fmoc-Pra-TTY-Az4 8.02 : 1
24 (TTW-Tz4)cy Fmoc-Pra-TTW-Az4 59.1 : 0
25 (TTF-Tz4)cy Fmoc-Pra-TTF-Az4 6.28 : 1
26 (TTV-Tz4)cy Fmoc-Pra-TTV-Az4 6.34 : 1