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. 2021 Jan 27;11(8):4842–4852. doi: 10.1039/d0ra07491h

CuAAC cyclization of peptides containing seven to ten amino acids.

Peptide Cyclic peptide Linear peptide Precursor Monomer : dimer Number of amino acids
1 (YYTYTTz4)cy Fmoc-Pra-YYTYT-Az4 8.28 : 1 7
9 (AYYTYT-Tz4)cy Fmoc-Pra-AYYTYT-Az4 3.06 : 1 8
10 (AAYYTYT-Tz4)cy Fmoc-Pra-AAYYTYT-Az4 1 : 3.98 9
11 (AAAYYTYT-Tz4)cy Fmoc-Pra-AAAYYTYT-Az4 1 : 4.5 10