CuAAC cyclization of peptides containing seven to ten amino acids.
Peptide | Cyclic peptide | Linear peptide Precursor | Monomer : dimer | Number of amino acids |
---|---|---|---|---|
1 | (YYTYTTz4)cy | Fmoc-Pra-YYTYT-Az4 | 8.28 : 1 | 7 |
9 | (AYYTYT-Tz4)cy | Fmoc-Pra-AYYTYT-Az4 | 3.06 : 1 | 8 |
10 | (AAYYTYT-Tz4)cy | Fmoc-Pra-AAYYTYT-Az4 | 1 : 3.98 | 9 |
11 | (AAAYYTYT-Tz4)cy | Fmoc-Pra-AAAYYTYT-Az4 | 1 : 4.5 | 10 |