Effect of short peptide length on CuAAC cyclization on-bead.
Peptide | Cyclic peptide | Linear peptide precursor | M : D | Number of amino acids |
---|---|---|---|---|
1 | (YYTYT-Tz4)cy | Fmoc-Pra-YYTYT-Az4 | 8.28 : 1 | 7 |
14 | (YTYT-Tz4)cy | Fmoc-Pra-YTYT-Az4 | 6.68 : 1 | 6 |
15 | (TYT-Tz4)cy | Fmoc-Pra-TYT-Az4 | 1.90 : 1 | 5 |