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. 2021 Jan 27;11(8):4842–4852. doi: 10.1039/d0ra07491h

Effect of short peptide length on CuAAC cyclization on-bead.

Peptide Cyclic peptide Linear peptide precursor M : D Number of amino acids
1 (YYTYT-Tz4)cy Fmoc-Pra-YYTYT-Az4 8.28 : 1 7
14 (YTYT-Tz4)cy Fmoc-Pra-YTYT-Az4 6.68 : 1 6
15 (TYT-Tz4)cy Fmoc-Pra-TYT-Az4 1.90 : 1 5