CuAAC Cyclization of pentameric peptides with same amino acids but different sequences.
Peptide | Cyclic peptide sequence | Linear peptide precursor | Monomer : dimer |
---|---|---|---|
15 | (TYT-Tz4)cy | Fmoc-Pra-TYT-Az4 | 1.90 : 1 |
16 | (YTT-Tz4)cy | Fmoc-Pra-YTT-Az4 | 3.72 : 1 |
17 | (TTY-Tz4)cy | Fmoc-Pra-TTY-Az4 | 8.02 : 1 |