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. 2021 Jan 27;11(8):4842–4852. doi: 10.1039/d0ra07491h

CuAAC Cyclization of pentameric peptides with same amino acids but different sequences.

Peptide Cyclic peptide sequence Linear peptide precursor Monomer : dimer
15 (TYT-Tz4)cy Fmoc-Pra-TYT-Az4 1.90 : 1
16 (YTT-Tz4)cy Fmoc-Pra-YTT-Az4 3.72 : 1
17 (TTY-Tz4)cy Fmoc-Pra-TTY-Az4 8.02 : 1