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. 2021 Jan 27;11(8):4842–4852. doi: 10.1039/d0ra07491h

Cyclization of pentameric peptides with variable 2nd residue from N-terminal.

Peptide Cyclic peptide Linear peptide precursor Monomer : dimer
16 (YTT-Tz4)cy Fmoc-Pra-YTT-Az4 3.72 : 1
18 (VTT-Tz4)cy Fmoc-Pra-VTT-Az4 1.94 : 1
19 (FTT-Tz4)cy Fmoc-Pra-FTT-Az4 1.83 : 1
20 (WTT-Tz4)cy Fmoc-Pra-WTT-Az4 4.74 : 1