Cyclization of pentameric peptides with variable 2nd residue from N-terminal.
Peptide | Cyclic peptide | Linear peptide precursor | Monomer : dimer |
---|---|---|---|
16 | (YTT-Tz4)cy | Fmoc-Pra-YTT-Az4 | 3.72 : 1 |
18 | (VTT-Tz4)cy | Fmoc-Pra-VTT-Az4 | 1.94 : 1 |
19 | (FTT-Tz4)cy | Fmoc-Pra-FTT-Az4 | 1.83 : 1 |
20 | (WTT-Tz4)cy | Fmoc-Pra-WTT-Az4 | 4.74 : 1 |