Fig. 5.

MYC has multiple effects on the DNA damage response. MYC is essential for NBS1 expression and the activity of ATM and its downstream effectors such as p53. In turn, p53 suppresses MYC expression in a pulsatile pattern. MYC drives cell fate toward apoptosis and overrides cell cycle arrest. MYC also participates in the generation of DNA damage. DNA repair impairment, ROS generation, and increased replication stress are among other MYC-provoked DNA damage response mechanisms