Table 3.
Treatment adherence and discontinuation at 1 year after treatment initiation.
| Age group, years | ||||
|---|---|---|---|---|
| 18–30a(N = 773) | 31–40(N = 1,468) | 41–50(N = 1,630) | ≥51 (N = 1,469) | |
| Adherence to treatment | ||||
| Nb | 577 | 1,103 | 1,244 | 1,117 |
| Mean MPR, % (SD) | 87.55 (12.80) | 87.73 (14.07) | 88.73 (12.73) | 89.51 (12.48) |
| Adherent, n (%)c | 448 (77.6) | 878 (79.6) | 1,012 (81.3) | 938 (84.0) |
| Non-adherent, n (%)d | 129 (22.4) | 225 (20.4) | 232 (18.7) | 179 (16.0) |
| Treatment discontinuation | ||||
| Number of events | 334 | 600 | 673 | 583 |
| Patient years | 417.97 | 821.84 | 937.95 | 848.48 |
| IR (95% CI) | 79.91 (71.57–88.96) | 73.01 (67.28–79.09) | 71.75 (66.43–77.38) | 68.71 (63.25–74.52) |
| HR (95% CI)e | – | 0.92 (0.81–1.05) | 0.92 (0.80–1.05) | 0.88 (0.77–1.01) |
a
Reference group for treatment discontinuation.
b
Patients with data available for calculating MPR.
c
Adherent: MPR between 80 and 120%.
d
Non-adherent: MPR <80%.
e
HR calculated using a Cox proportional hazards model.
CI, confidence interval; HR, hazard ratio; IQR, interquartile range; IR, incidence rate; IRR, incidence rate ratio; MPR, medication possession ratio; SD, standard deviation.