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The underlying mechanisms of hypoxia-induced drug-resistant NSCLC. Tumors exposed to hypoxia is an important mediator of resistance to cisplatin and EGFR-TKIs in NSCLC that induce apoptosis-resistant pathways by mediating autophagy and reducing susceptibility to apoptosis, and then metabolic adaptations in tumor cells to hypoxia leads to chemoresistance, which switches on genetic pathways and metabolic changes.
