Figure 4.

Functional coupling to the dorsal raphe. Paclitaxel produces hyperconnectivity of functional coupling to the dorsal raphe that is attenuated by vaporization of THC-enriched cannabis. The columns of 2D images show heat maps of significant connectivity (z values) for each experimental condition. The shades of red (positive connectivity) and blue (negative connectivity) appear on anatomical sections taken from the rat brain atlas. These sections are identical across rows (A–F). Yellow highlights white matter tracts, and black shows the location of the dorsal raphe in (C). The brain areas with significant connectivity to the dorsal raphe were taken from Table 1. The most rostral brain areas in Table 1 (e.g., anterior olfactory nucleus) are not shown in these 2D sections but are displayed in the 3D color-coded reconstruction of the placebo paclitaxel and THC paclitaxel conditions below. ctx, cortex; n., nucleus; THC, Δ⁹-tetrahydrocannabinol.