Table 2.
Association of fetal APOL1 risk alleles with risk of preeclampsia
| Group | APOL1 risk allele | Cont., n(%) | Cases, n(%) | ORa | 95%CIa | Pa |
|---|---|---|---|---|---|---|
| Total | 0 | 110 (52.9) | 91 (43.5) | Ref | 1.00–1.00 | |
| 1 | 79 (38.0) | 90 (43.1) | 1.17 | 0.73–1.87 | 0.5 | |
| 2b | 19 (9.1) | 28 (13.4) | 1.79 | 0.87–3.70 | 0.1 | |
| Recessive | 19 (9.1) | 28 (13.4) | 1.67 | 0.83–3.34 | 0.2 | |
| Dominant | 98 (47.1) | 118 (56.5) | 1.28 | 0.83–1.99 | 0.3 | |
| Additive | - | - | 1.28 | 0.93–1.77 | 0.1 | |
| APOL1 × maternal country-of-origin Interaction† | ||||||
| APOL1 risk allele in a recessive model | 0.04 | |||||
| APOL1 risk allele in an dominant model | 0.2 | |||||
| APOL1 risk allele in a additive model | 0.05 | |||||
| Stratified by maternal origin of country | ||||||
| African-Americans | 0 | 74 (55.6) | 54 (40.3) | Ref | 1.00–1.00 | |
| 1 | 52 (39.1) | 59 (44.0) | 1.35 | 0.75–2.44 | 0.3 | |
| 2c | 7 (5.3) | 21 (15.7) | 4.06 | 1.43–11.6 | 0.009 | |
| Recessive | 7 (5.3) | 21 (15.7) | 3.55 | 1.29–9.74 | 0.01 | |
| Dominant | 59 (44.4) | 80 (59.7) | 1.64 | 0.94–2.87 | 0.08 | |
| Additive | - | - | 1.72 | 1.11–2.64 | 0.01 | |
| Haitian† | 0 | 36 (48.0) | 37 (49.3) | Ref | 1.00–1.00 | |
| 1 | 27 (36.0) | 31 (41.3) | 0.93 | 0.42–2.07 | 0.9 | |
| 2d | 12 (16.0) | 7 (9.3) | 0.55 | 0.17–1.78 | 0.3 | |
| Recessive | 12 (16.0) | 7 (9.3) | 0.57 | 0.18–1.74 | 0.3 | |
| Dominant | 39 (52.0) | 38 (50.6) | 0.81 | 0.39–1.71 | 0.6 | |
| Additive | 0.79 | 0.46–1.35 | 0.4 | |||
Shown are the association of fetal APOL1 risk alleles with risk of preeclampsia, stratified by maternal country-of-origin.
a
Adjusted for pre-pregnancy BMI category, smoking status during pregnancy, alcohol drinking during pregnancy, chronic hypertension, country-of-origin (for the analyses in the total sample only) and years the mothers stayed in the US;
b,c,d
The 2-degree of freedom test was performed for APOL1 risk allele, with bP=0.3 in the total sample, cP= 0.02 in African Americans, and dP=0.6 in Haitian subset.
†
In the interaction test, maternal country-of-origin was traited as a binary variable with the “African-American” category as the reference group.