Table 3.
Bioactivity of D. antarctica-Derived Spongian Diterpenes and Their Methanolysis Products (IC50, μM)
| compound | Leishmania donovani IM | cytotoxicity (J774A.1) |
|---|---|---|
| aplysulphurin (1) | 3.1 | 12.3 |
| tetrahydroaplysulphurin-1 (2) | 3.5 | >133 |
| membranolide (3) | 9.7 | 76.8 |
| darwinolide (4) | 11.2 | 73.4 |
| membranoid A (5) | >29.0 | 54.6 |
| membranoid B (6) | 0.8 | >133 |
| membranoid C (7) | 6.5 | >133 |
| membranoid D (8) | 1.4 | >133 |
| membranoid E (9) | 6.6 | 95.0 |
| membranoid F (10) | 26.7 | 42.4 |
| membranoid G (11) | 1.9 | >150 |
| membranoid H (12) | 12.0 | 62.9 |
a
Positive control, miltefosine = 2.9 μM (IM), >120 μM (Cytotox).