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Similarity between S. pyogenes and GBS pbp2b deletion mutant strain. (A) Spectrum of essential PBP genes in WT GBS, GBS pbp2b deletion mutant, and S. pyogenes. (B) In both serotype M1 and M28 S. pyogenes, insertion inactivation of pbp1a is not tolerated, except for the last ∼10% of the coding sequence.
