FIG 4.

Copy number analysis by deep sequencing in topA mutant derivatives of MDS42. Relative copy numbers are plotted as semi-log graphs for overlapping 10-kb intervals across the genome (the relevant genotype of each strain is indicated at the top of each panel); positions of oriC, TerA, and TerC/B are marked, and the gap at around 0.3 Mbp in each of the plots corresponds to the argF-lac deletion present in the strains. Strains used for the different panels are as follows: i, GJ12134; ii, GJ16819; iii, GJ18977; and iv, GJ17777.