Table 1. Tissue-specific age-dysregulated functions.
| Tissue | Module | Summary network meta-node | Summary network FDR | No. of nodes | Meta-node choice criteria | Genes involved | WGCNA expression trend | WGCNA expression shift |
| Brain | Tan | mediated immunoglobulin regulation response | 8.06E-03 | 142 | Largest | B2m, C1qa, C1qb, C1qc, C3, C4b, Csf1, Ctsh, Ctss, Ctsz, Cx3cr1, Gfap, H2-D1, H2-K1, H2-T23, Hexb, Il33, Irf7, Itgb2, Lag3, Lgals3, Neat1, Psmb8, Serpina3n, Slc11a1, Tap2, Tapbp | Increasing with age | Middle to old-age - 15-18 months |
| Brain | Tan | neuron death activation microglial | 6.59E-03 | 7 | Most significant | C1qa, Csf1, Ctsz, Cx3cr1, Il33, Slc11a1 | Increasing with age | Middle to old-age - 15-18 months |
| Heart | Blue | branched-chain amino process metabolic | 1.57E-02 | 17 | Largest | Acaa2, Adk, Auh, Ckm, Ckmt2, Cyc1, Eno3, Gnpat, Hmgcl, Isca1, Mccc2, Nfs1, Pdhb, Suclg1 | Decreasing with age | Old-age - 18-21 months |
| Heart | Blue | acid catabolic lipid fatty | 4.19E-04 | 12 | Most significant | Acaa1a, Acaa2, Adipor1, Auh, Eci2, Etfb, Gnpat, Hadh, Hmgcl, Mccc2, Pgm2, Phyh, Ptges2, Smpd1 | Decreasing with age | Old-age - 18-21 months |
| Liver | Darkturquoise | response immune regulation cell | 7.07E-03 | 57 | Both | Cd19, Cd79a, Cd79b, Ighm, Igkc, Igkv3-5, Iglc2, Jchain, Mzb1 | Increasing with age | Adulthood to middle-age - 6-9 months |
| Liver | Salmon | regulation assembly cell positive | 3.32E-02 | 184 | Both | Ccl5, H2-Aa, H2-Eb1, Ntrk2, Slamf7 | Increasing with age | Middle-age - 9-12 months |
| Liver | Blue | lipid biosynthetic process | 3.43E-02 | 1 | Both | Cdipt, Elovl2, Elovl3, Hsd17b12, Mecr, Pip5k1a, Pisd, Rest, Scp2, Serinc1, Smpd1 | Decreasing with age (males) | Old-age - 24-27 months |
| Liver | Cyan | endoplasmic reticulum golgi vesicle-mediated | 2.80E-03 | 4 | Most significant | Arcn1, Copg1, Sec22b, Sec24d | Decreasing with age (males) | Old-age - 18-21 months |
| Liver | Cyan | protein transmembrane response development | 1.41E-02 | 21 | Largest | Arcn1, Copg1, Hspa5, Sdf2l1, Sec22b, Sec24d, Sec61a1, Serp1 | Decreasing with age (males) | Old-age - 18-21 months |
| Muscle | Brown | regulation morphogenesis negative development | 1.12E-02 | 82 | Both | Angptl1, Anxa2, Cd34, Col3a1, Col5a1, Col5a2, Col6a1, Col6a2, Col6a3, Dok2, Fn1, Igfbp6, Itgbl1, Lrp1, Ndn, Nid1, Pi16, Serpinf1, Serping1, Sparc, Ssc5d, Tgfbi, Timp2 | Decreasing with age | Middle-age - 9-12 months |
| Muscle | Blue | proteasomal ubiquitin-independent protein catabolic | 1.78E-02 | 1 | Most significant | Psmb1, Psmb3 | Increasing with age (males) | Middle-age - 9-12 months |
| Muscle | Blue | ribonucleoside triphosphate metabolic process | 2.89E-02 | 13 | Largest | Atp5l, Atp5g3, Cox5a, Ndufa8 | Increasing with age (males) | Middle-age - 9-12 months |
The choice of the representative meta-nodes was based on the number of nodes (GO terms) included (Largest) and/or on the p-values (Most significant). In the sex-associated modules, the sex in which the genes are enriched is indicated inside parentheses. Relates to Supplementary Table 6.