Table 2. Target information of GF against AD.

Number	Gene ID	Protein description	Gene symbol	Number	Gene ID	Protein description	Gene symbol
1	25	ABL proto-oncogene 1, non-receptor tyrosine kinase	ABL1	43	3832	kinesin family member 11	KIF11
2	43	acetylcholinesterase (Cartwright blood group)	ACHE	44	3815	KIT proto-oncogene, receptor tyrosine kinase	KIT
3	6868	ADAM metallopeptidase domain 17	ADAM17	45	3932	LCK proto-oncogene, Src family tyrosine kinase	LCK
4	135	adenosine A2a receptor	ADORA2A	46	4128	monoamine oxidase A	MAOA
5	136	adenosine A2b receptor	ADORA2B	47	4233	MET proto-oncogene, receptor tyrosine kinase	MET
6	185	angiotensin II receptor type 1	AGTR1	48	4311	membrane metalloendopeptidase	MME
7	196	aryl hydrocarbon receptor	AHR	49	4312	matrix metallopeptidase 1	MMP1
8	207	AKT serine/threonine kinase 1	AKT1	50	4321	matrix metallopeptidase 12	MMP12
9	240	arachidonate 5-lipoxygenase	ALOX5	51	4313	matrix metallopeptidase 2	MMP2
10	328	apurinic/apyrimidinic endodeoxyribonuclease 1	APEX1	52	4314	matrix metallopeptidase 3	MMP3
11	83464	aph-1 homolog B, gamma-secretase subunit	APH1B	53	4318	matrix metallopeptidase 9	MMP9
12	351	amyloid beta precursor protein	APP	54	4353	myeloperoxidase	MPO
13	427	N-acylsphingosine amidohydrolase 1	ASAH1	55	4543	melatonin receptor 1A	MTNR1A
14	23621	beta-secretase 1	BACE1	56	23385	nicastrin	NCSTN
15	590	butyrylcholinesterase	BCHE	57	4843	nitric oxide synthase 2	NOS2
16	728	complement C5a receptor 1	C5AR1	58	7376	nuclear receptor subfamily 1 group H member 2	NR1H2
17	823	calpain 1	CAPN1	59	4915	neurotrophic receptor tyrosine kinase 2	NTRK2
18	595	cyclin D1	CCND1	60	5027	purinergic receptor P2X 7	P2RX7
19	983	cyclin dependent kinase 1	CDK1	61	142	poly(ADP-ribose) polymerase 1	PARP1
20	1020	cyclin dependent kinase 5	CDK5	62	5142	phosphodiesterase 4B	PDE4B
21	1071	cholesteryl ester transfer protein	CETP	63	5144	phosphodiesterase 4D	PDE4D
22	1080	CF transmembrane conductance regulator	CFTR	64	5159	platelet derived growth factor receptor beta	PDGFRB
23	1129	cholinergic receptor muscarinic 2	CHRM2	65	5328	plasminogen activator, urokinase	PLAU
24	1139	cholinergic receptor nicotinic alpha 7 subunit	CHRNA7	66	5340	plasminogen	PLG
25	1269	cannabinoid receptor 2	CNR2	67	5465	peroxisome proliferator activated receptor alpha	PPARA
26	1312	catechol-O-methyltransferase	COMT	68	5467	peroxisome proliferator activated receptor delta	PPARD
27	1508	cathepsin B	CTSB	69	5468	peroxisome proliferator activated receptor gamma	PPARG
28	1509	cathepsin D	CTSD	70	5663	presenilin 1	PSEN1
29	1612	death associated protein kinase 1	DAPK1	71	5664	presenilin 2	PSEN2
30	2099	estrogen receptor 1	ESR1	72	55851	presenilin enhancer, gamma-secretase subunit	PSENEN
31	2100	estrogen receptor 2	ESR2	73	9536	prostaglandin E synthase	PTGES
32	2558	gamma-aminobutyric acid type A receptor subunit alpha5	GABRA5	74	5737	prostaglandin F receptor	PTGFR
33	2902	glutamate ionotropic receptor NMDA type subunit 1	GRIN1	75	5743	prostaglandin-endoperoxide synthase 2	PTGS2
34	2903	glutamate ionotropic receptor NMDA type subunit 2A	GRIN2A	76	5914	retinoic acid receptor alpha	RARA
35	2904	glutamate ionotropic receptor NMDA type subunit 2B	GRIN2B	77	5915	retinoic acid receptor beta	RARB
36	2932	glycogen synthase kinase 3 beta	GSK3B	78	6531	solute carrier family 6 member 3	SLC6A3
37	3091	hypoxia inducible factor 1 subunit alpha	HIF1A	79	6532	solute carrier family 6 member 4	SLC6A4
38	27306	hematopoietic prostaglandin D synthase	HPGDS	80	6646	sterol O-acyltransferase 1	SOAT1
39	3290	hydroxysteroid 11-beta dehydrogenase 1	HSD11B1	81	706	translocator protein	TSPO
40	3363	5-hydroxytryptamine receptor 7	HTR7	82	7276	transthyretin	TTR
41	3783	potassium calcium-activated channel subfamily N member 4	KCNN4	83	7415	valosin containing protein	VCP
42	3791	kinase insert domain receptor	KDR	84	7421	vitamin D receptor	VDR