Table 5. KEGG pathway analysis of genes with up-regulated methylation.
| Pathway ID | Definition | P-value | Count | Genes |
| rno04512 | ECM-receptor interaction | 2.54915E-10 | 83 | COL1A1/COL1A2/COL4A1/COL4A2/ COL4A3/COL6A1/COL6A2/COL6A3/ COL6A6/ CD44/ FN1/HMMR, etc. |
| rno04151 | PI3K-Akt signaling pathway | 0.000162593 | 332 | COL1A1/COL1A2/COL4A1/COL4A2/ COL4A3/COL6A1/COL6A2/COL6A3/ CCND3/CCNE1/ EFNA1/EIF4B, etc. |
| rno04611 | Platelet activation | 0.001133334 | 124 | COL1A1/COL1A2/COL3A1/F2RL3/ FERMT3/FGG/APBB1IP/ARHGEF1/ BTK/ FGG/ITGA2/ LCP2, etc. |
| rno04062 | Chemokine signaling pathway | 0.003441997 | 177 | NF-κB1/ARRB2/CCL9/CCR5/ CXCL12/CXCL2/CXCL9/GNB1/ GNG2/GNGT2/MAP2K1, etc. |
| rno00010 | Glycolysis/ gluconeogenesis | 0.02539777 | 70 | GPI/HK3/LDHA/ PKM/ PCK2/ DLD/ PGAM1/ADH1/ALDH9A1/BPGM |
| rno04662 | B cell receptor signaling pathway | 0.03293257 | 73 | NF-κB1/ BTK/CD72/DAPP1/INPP5D/ MALT1/MAP2K1 /PIK3AP1/PPP3R1/ PTPN6 |
| rno04066 | HIF-1 signaling pathway | 0.0422345 | 108 | NF-κB1/CYBB/HK3/HMOX1/ STAT3/ IFNGR1/IGF1/LDHA/MAP2K1/PFKFB3/ PRKCA/SERPINE1/TIMP1 |
| rno04660 | T cell receptor signaling pathway | 0.0422345 | 108 | NF-κB1/CBLB/CD4/CTLA4/ICOS/ LCP2/MALT1/MAP2K1/PAK1/PAK2/ PPP3R1/PTPN6/PTPRC |
“Count” stands for the count of the chosen background population genes' entities associated with the listed Pathway ID.