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. 2021 Jul 16;13(14):18376–18391. doi: 10.18632/aging.203285

Table 3. Crude and adjusted hazards ratios (95% confidence intervals) for incident type 2 diabetes mellitus (T2DM) during the follow-up from March 2008 to December 2012 by baseline RGS-TUG score and stratified by obesity status.

Number Incidence of T2DM per 100 person-year Crude model HR (95% CI) Adjusted model HR (95% CI)
Total
RGS-TUG score
4 (best) 583 0.08 0.00 0.00
3 915 0.11 1.42 (0.82, 2.44) 1.29 (0.73, 2.29)
2 1,124 0.13 1.68 (1.00, 2.81)* 1.53 (0.88, 2.66)
1 785 0.18 2.43 (1.45, 4.07)** 1.78 (0.98, 3.22)
0 (poorest) 485 0.29 3.76 (2.24, 6.32)*** 2.87 (1.52, 5.41)**
P for trend <0.001 0.001
Normal weight
RGS-TUG score
4 (best) 436 0.07 0.00 0.00
3 645 0.07 1.07 (0.52, 2.21) 0.78 (0.36, 1.67)
2 739 0.09 1.38 (0.70, 2.72) 0.88 (0.42, 1.84)
1 448 0.15 2.39 (1.22, 4.68)* 0.91 (0.40, 2.08)
0 (poorest) 204 0.15 2.37 (1.08, 5.18)* 0.94 (0.34, 2.56)
P for trend 0.001 0.96
Overweight/obesity
RGS-TUG score
4 (best) 100 0.12 0.00 0.00
3 221 0.26 2.14 (0.81, 5.64) 2.22 (0.82, 6.03)
2 335 0.23 1.95 (0.76, 5.00) 2.05 (0.76, 5.54)
1 318 0.24 2.06 (0.80, 5.29) 1.96 (0.70, 5.47)
0 (poorest) 277 0.40 3.35 (1.33, 8.44)* 3.01 (1.04, 8.69)*
P for trend 0.006 0.12

RGS-TUG score: a composite score of relative grip strength (RGS) and timed up and go (TUG) test, with 4 indicating best physical function and 0 indicating poorest physical function.

Incident T2DM: defined by a history of self-reported physician-diagnosed diabetes or glucose-lowering treatment during follow up or fasting glucose ≥7.0 mmol/l or 2hPG ≥11.1 mmol/l and without T2DM at baseline; Normal weight: 18.5 kg/m2 ≤ BMI <25 kg/m2; Overweight/obesity: BMI ≥25 kg/m2.

adjusting for sex, age, education, occupation, smoking status, alcohol use and self-rated health.

*P < 0.05; **P < 0.01; ***P < 0.001.