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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: JAMA Pediatr. 2021 Apr 1;175(4):404–409. doi: 10.1001/jamapediatrics.2020.5801

Table 1.

Original Hierarchy of Strength of Evidence for Treatment Decisions (Guyatt et al 2002).1

N-of-1 Randomized Trial
Systematic reviews of randomized trials
Single randomized trial
Systematic review of observational studies addressing patient-important outcomes
Single observational study addressing patient-important outcomes
Physiologic studies
Unsystematic clinical observations