Table 2:

Potential Topics for Future Research Efforts on Inflammatory/Fibrotic Mechanisms in HFpEF.

1	Inflammatory signaling in obese, mostly female HFpEF patients with isolated CRP elevation
2	Involvement of myofilamentary proteins especially titin in nitrosative stress induced proteotoxicity
3	Gender related protective mechanisms against nitrosative stress induced proteotoxicity
4	Proinflammatory effects of microvascular endothelial upregulation of glycolytic enzymes
5	Blunted microvascular upregulation of adhesion molecules in the presence of elevated plasma high density lipoproteins
6	Linkage between overload induced basal lamina deformation and secretion of proinflammatory cytokines in cardiomyocytes
7	Molecular/cellular regulatory mechanisms that control myocardial fibrosis