Table 3.
Univariate and Multivariable Analyses for Predictors of Initial Clinical Failure, Stratified by Treatment Regimen
| MTZ-Based Treatment Regimen (n = 255) | Non-MTZ-Based Treatment Regimen (n = 101) | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariable | Univariate | Multivariable | |||||
| Predictor | Odds Ratio (95% CI) | P Value | Odds Ratio (95% CI) | P Value | Odds Ratio (95% CI) | P Value | Odds Ratio (95% CI) | P Value |
| MTZ MIC ≥1 µg/mL | 2.60 (1.38–4.91) | .003 | 2.27 (1.18–4.34) | .014 | 2.18 (.63–7.55) | .22 | 3.15 (.83–11.94) | .09 |
| Age (per 1-year increase) | 0.99 (.98–1.01) | .49 | 0.99 (.97–1.00) | .15 | 0.97 (.94–.99) | .017 | 0.96 (.93–.99) | .004 |
| CCI score (per 1-unit increase) | 1.11 (.97–1.26) | .14 | 1.01 (.94–1.26) | .24 | 1.17 (.95–1.44) | .13 | 1.25 (.99–1.57) | .05 |
| Severe/fulminant CDI | 2.67 (1.47–4.84) | .001 | 2.56 (1.33–4.44) | .004 | 0.55 (.22–1.33) | .18 | 0.54 (.20–1.49) | .24 |
Bolded values indicate those deemed significant with a P value < .05.
Abbreviations: CCI, Charlson Comorbidity Index; CDI, Clostridioides difficile infection; CI, confidence interval; MIC, minimum inhibitory concentration; MTZ, metronidazole.