Table 1.
Characteristics of studies included in the meta-analysis
| Study | Year | Country | Age, mean ± SD, year | Gender(male/female) | Diagnostic criteria | Genotype (case/control) | PHWE | ||||
| case | control | case | control | WT Ho | Ht | VR Ho | |||||
| rs2854116 | TT | TC | CC | ||||||||
| Cai et al. | 2013 | China (Han) |
43.68±10.72 | 42.88±10.0 | NA | NA | The criteria of NAFLD designed by the Chinese Liver Disease Association (2010) |
51/70 | 109/103 | 33/38 | 0.992 |
| Cai et al. | 2013 | China (Uyghur) |
42.39±8.79 | 41.59±9.07 | NA | NA | The criteria of NAFLD designed by the Chinese Liver Disease Association (2010) |
56/54 | 115/94 | 32/40 | 0.939 |
| Li M et al. | 2014 | China | 40.7±9.7 | 39.5±9.1 | 200/100 | 200/100 | Ultrasonography | 94/134 | 131/123 | 75/43 | 0.093 |
| Niu et al. | 2014 | China | 49.76±16.17 | 47.69±15.86 | 175/215 | 198/211 | The criteria of NAFLD designed by the AASID |
102/104 | 180/195 | 108/110 | 0.350 |
| Niu et al. | 2014 | China | 49.96±16.20 | 47.81±16.19 | 132/155 | 146/164 | The criteria of NAFLD designed by the Chinese Liver Disease Association (2010) |
81/80 | 139/147 | 67/83 | 0.364 |
| Puppala et al. |
2014 | India | 44.1±12.1 | 42.6±10.6 | 92/58 | 92/58 | Ultrasonography | 44/60 | 75/81 | 31/9 | 0.007 |
| Song et al. | 2017 | China | NA | NA | 39/93 | 94/158 | The criteria of NAFLD designed by the Chinese Liver Disease Association (2010) |
44/88 | 63/117 | 23/46 | 0.517 |
| Yang et al. |
2018 | China | 70.95±4.73 | 72.53±5.67 | 25/72 | 133/229 | Guidelines for management of nonalcoholic fatty liver disease: an updated and revised edition |
39/135 | 46/177 | 12/50 | 0.506 |
| rs2854117 | |||||||||||
| Cai et al. | 2013 | China (Han) |
43.68±10.72 | 42.88±10.0 | NA | NA | The criteria of NAFLD designed by the Chinese Liver Disease Association (2010) |
52/71 | 106/99 | 35/41 | 0.539 |
| Cai et al. | 2013 | China (Uyghur) |
42.39±8.79 | 41.59±9.07 | NA | NA | The criteria of NAFLD designed by the Chinese Liver Disease Association (2010) |
73/71 | 105/86 | 25/31 | 0.567 |
| Li et al. | 2014 | China | 40.7±9.7 | 39.5±9.1 | 200/100 | 200/100 | The criteria of NAFLD designed by the Chinese Liver Disease Association (2010) |
108/126 | 144/127 | 48/47 | 0.118 |
| Niu et al. | 2014 | China | 49.76±16.17 | 47.69±15.86 | 175/215 | 198/211 | The criteria of NAFLD designed by the AASID |
107/104 | 176/203 | 107/102 | 0.882 |
| Niu et al. | 2014 | China | 49.96±16.20 | 47.81±16.19 | 132/155 | 146/164 | The criteria of NAFLD designed by the Chinese Liver Disease Association (2010) |
81/79 | 132/156 | 74/75 | 0.907 |
| Puppala et al. |
2014 | India | 44.1±12.1 | 42.6±10.6 | 92/58 | 92/58 | Ultrasonography | 55/62 | 57/46 | 38/42 | 0.000 |
HWE, Hardy-Weinberg equilibrium; PHWE was calculated by goodness-of fit χ2-test, PHWE < 0.05 was considered statistically significant; NA, not available. Ht, heterozygote; VR Ho, variant homozygote; WT Ho, wide-type homozygote.