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. Author manuscript; available in PMC: 2021 Aug 9.
Published in final edited form as: Biochim Biophys Acta Gene Regul Mech. 2020 Sep 2;1864(2):194629. doi: 10.1016/j.bbagrm.2020.194629

Figure 1: Acetylation efficiency of different Gcn5-containing complexes.

Figure 1:

The Gcn5 catalytic subunit possesses weak histone acetyltransferase activity on its own. Ada2 increases HAT activity on histones, and Ada3 is needed for robust nucleosome acetyltransferase activity. Sgf29 mediates processive acetylation and completes the SAGA HAT module. Comparison of HAT activity based on Balasubramanian et al, 2002 [8] and Ringel et al, 2015 [46].