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. Author manuscript; available in PMC: 2021 Aug 9.
Published in final edited form as: Biochim Biophys Acta Gene Regul Mech. 2020 Sep 2;1864(2):194629. doi: 10.1016/j.bbagrm.2020.194629

Figure 7: Mechanism of phosphorylation-acetylation epigenetic histone modification crosstalk.

Figure 7:

Histone H3 S10 phosphorylation induces conformational changes in the H3 peptide that increase its interactions with the catalytic site of Tetrahymena Gcn5 (compare H3 Thr11 positions), increasing the binding affinity for the substrate. Key Gcn5 residues that mediate these interactions are shown. Molecular graphics prepared in PyMOL using PDB coordinates 1PU9 and 1PUA.