Table 1.
Top disease and functions gene networks on regulated immune genes for the chronically infected group identified by the IPA software.
| Top Diseases and Functions | Score | Focus molecules | Molecules in Network |
|---|---|---|---|
| Cell-to-cell signaling and interaction, hematological system development and function, lymphoid tissue structure and development | 24 | 12 | Arginase, CD4, CD40, CD8, CD8A, Ctbp, Cyclooxygenase, CYP, IFN, IFN Beta, IFNG, IgE, IL-12 (family), IL12B, IL2RA, immune complex, Interferon alpha, LIF, MHC Class I complex, MHC CLASS I (family), MHC Class II (complex), Mst/krs, NAD, NFKB2, NGF, NOS, Pias, Pro-inflammatory Cytokine, SOCS1, SOCS2, STAT5 a/b, STAT6, TLR, TLR2/3/4/9, TNF (family) |
| Cell Death and Survival, Free Radical Scavenging, Molecular Transport | 19 | 10 | 26s Proteasome, ADRB, Alp, Ant, BAX, BCL2, BCL2L1, Calcineurin A, Calcineurin protein(s), calpain, Caspase, CD40LG, CG, creatine kinase, CSF2, CXCL10, Cytochrome C, Cytochrome-c oxidase, DFF, FAS, FasLg, Growth factor, Hdac, HISTONE, Hsp70, Hsp90, IL1, ITPR, LDL-cholesterol, NOS2, Notch, P38 MAPK, Rb, Vdac, VEGFA |
| Cardiovascular disease, organismal injury and abnormalities, renal and urological disease | 12 | 7 | ACE, Alpha Actinin, Alpha catenin, Alpha tubulin, CD34, Collagen, Collagen type I (complex), Collagen type II, Collagen type III, Collagen type IV, Collagen(s), collagenase, ECM, elastase, FGF, Fibrin, Granzyme, GZMB, IL7, Integrin, Integrin alpha V beta 3, Kallikrein, Laminin (complex), MMP, PKG, PROTEASE, SELP, Serine Protease, SKI, SMAD, TGF-B, TGF-B1, TH1 Cytokine, Thrombospondin, Trypsin |
| Connective tissue disorders, inflammatory disease, inflammatory response | 12 | 7 | Ap1, Beta Arrestin, CCL5, CCR4, Chemokine, Chemokine receptor, Cyclin B, Cytokine, Focal adhesion kinase, G protein, GPCR, IKBKB, IL10, IL2, MAPK, MTORC1, NFKB1, P110, p85 (pik3r), Pdgfr, PI3Kγ, PTK, Rac, RAS, Ras homolog, Receptor protein tyrosine kinase, RNA polymerase II, Secretase gamma, SELE, Sfk, Shc, SRC (family), STAT, TCR, VEGF |
| Cell signaling, cell-to-cell signaling and interaction, hematological system development and function | 10 | 6 | 14-3-3, Alpha actin, C-C chemokine receptor, Calcineurin B, Caspase 3/7, CCL3, CD28, CD3, CD3-TCR, CD3E, CXCL11, CXCR3, Gm-Csf Receptor, H/K/NRAS, HLA-DR, IFNG, IL-2R, IL-10R, IL-8r, Importin beta, JNK, Lamin b, Lfa-1, NADPH oxidase, NFAT (family), NFATC3, Pdgf (complex), PI3K (family), PI3K p85, Plc beta, Raf, Rap1, SAPK, SOS, TSH |