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. 2021 Jul 26;15:660773. doi: 10.3389/fncel.2021.660773

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Copyright © 2021 Pottackal, Singer and Demb.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct VGCC populations mediate transmitter release from SAC synapses onto DSGCs and SACs. (A) ChR2-evoked IPSCs (A1) and EPSCs (A2) in ON-OFF DSGCs and IPSCs in ON SACs (A3) before and during bath application of ω-conotoxin G6A (ctx G6A, 300 nM), an N-type VGCC blocker. (B) Peak amplitudes (I_peak) of ChR2-evoked IPSCs (B1, n = 7) and EPSCs (B2, n = 7) in ON-OFF DSGCs and IPSCs in ON SACs (B3, n = 5) before and during ω-conotoxin G6A application. (C) Residual fractions of peak amplitude following ω-conotoxin G6A application. (D) ω-conotoxin G6A sensitivities of ChR2-evoked GABAergic IPSCs (I_GABA) and cholinergic EPSCs (I_ACh) measured in the same ON-OFF DSGCs (n = 7). Residual fractions of peak amplitude (I_peak) or charge transfer (Q_trans) during ctx G6A application. n.s., not significant; **p < 0.01; ***p < 0.001.