Figure 4.

APD Alternans and APD Alternans Spatial Discordance in Young SHRs

(A) (Left) A graph showing LV APD alternans at different pacing rates. There was no difference in APD alternans between ibrutinib-treated and control hearts (n = 4 in control group; n = 5 in ibrutinib group). (Right) Representative APD alternans at 10.0 Hz showed no difference. (B) There was no difference in LV APD alternans spatial discordance in young SHRs between ibrutinib-treated and control hearts. (B1) Representative ΔAPD maps at 10.0 Hz in ibrutinib-treated and control hearts; (B2) Histograms showing the distributions of ΔAPD across the LV epicardium mapping area at 10.0 Hz. (x axis: ΔAPD [ms]; y axis: the number of points from the ΔAPD map); (B3) Quantification of APD alternans spatial discordance vs. pacing rates in ibrutinib-treated and control hearts (n = 4 in control group, n = 5 in ibrutinib group). Abbreviations as in Figures 1, 2, and 3.