Central Illustration.

Impact of Post-Transplant Cyclophosphamide on Early Cardiac Events and Overall Survival According to the Occurrence of These Cardiac Events

Post-transplant cyclophosphamide reduces the incidence of acute graft-versus-host disease. However, patients who receive post-transplant cyclophosphamide have a higher incidence of cardiac events within the first 100 days after allogeneic stem cell transplantation compared with patients who do not. Kaplan-Meier estimates (with a landmark analysis on day 100) show the detrimental impact of early cardiac events on overall survival. The 2-year overall survival was 47% in patients who had cardiac events compared with 72% in patients who did not (p = 0.046). CI = confidence interval; HR = hazard ratio.