Table 4.
Multivariable Analysis Associated With Early Cardiac Events, Relapse Incidence, and Survival
| HR (95% CI) | p Value | |
|---|---|---|
| Early cardiac event | ||
| PT-Cy (yes vs. no) | 2.65 (1.44–4.90) | 0.002 |
| Age (per 10 yrs) | 1.37 (1.09–1.73) | 0.007 |
| Sequential conditioning (vs. other) | 2.62 (1.45–4.75) | 0.001 |
| Cy exposure before HSCT (yes vs. no) | 2.69 (1.45–5.00) | 0.002 |
| Relapse incidence | ||
| PT-Cy (yes vs. no) | 1.09 (0.68–1.73) | 0.73 |
| DRI (high or very-high vs. low-intermediate) | 2.47 (1.56–3.91) | <0.001 |
| Cardiac event before HSCT (yes vs. no) | 1.85 (1.12–3.07) | 0.017 |
| Disease-free survival | ||
| PT-Cy (yes vs. no) | 1.15 (0.84–1.59) | 0.38 |
| DRI (high or very-high vs. low-intermediate) | 1.97 (1.33–2.90) | 0.001 |
| Sequential conditioning (vs. other) | 1.74 (1.18–2.55) | 0.005 |
| Cardiac event before HSCT (yes vs. no) | 1.94 (1.37–-2.75) | <0.001 |
| Cy exposure before HSCT (yes vs. no) | 1.77 (1.24–2.53) | 0.002 |
| Nonrelapse mortality | ||
| PT-Cy (yes vs. no) | 1.48 (0.94–2.33) | 0.09 |
| DRI (high/very-high vs. low-intermediate) | 2.07 (1.21–3.55) | 0.008 |
| Sequential conditioning (vs. other) | 1.86 (1.10–3.15) | 0.02 |
| Cardiac event before HSCT (yes vs. no) | 1.96 (1.20–3.20) | 0.008 |
| Cy exposure before HSCT (yes vs. no) | 2.22 (1.33–3.70) | 0.002 |
| Anthracycline (cumulative dose > median) | 0.99 (0.98–0.99) | 0.002 |
| Overall survival | ||
| PT-Cy (yes vs. no) | 1.19 (0.79–1.58) | 0.52 |
| DRI (high or very-high vs. low-intermediate) | 2.26 (1.56–3.28) | <0.001 |
| Disease status (CR vs. no CR) | 0.46 (0.31–0.69) | <0.001 |
| Cardiac event before HSCT (yes vs. no) | 1.83 (1.26–2.65) | 0.002 |
| Cy exposure before HSCT (yes vs. no) | 2.04 (1.40–2.98) | <0.001 |
| GRFS | ||
| PT-Cy (yes vs. no) | 1.02 (0.76–1.38) | 0.88 |
| DRI (high or very-high vs. low-intermediate) | 2.34 (1.73–3.17) | <0.001 |
| Cardiac event before HSCT (yes vs. no) | 1.40 (1.00–1.96) | 0.05 |
| Acute grade II–IV GVHD | ||
| PT-Cy (yes vs. no) | 0.61 (0.39–0.97) | 0.037 |
| Age (per 10 years) | 0.90 (0.79–1.05) | 0.18 |
| Chronic GVHD | ||
| PT-Cy (yes vs. no) | 1.01 (0.64–1.58) | 0.98 |
| Myeloablative conditioning (vs. other) | 1.70 (1.10–2.63) | 0.016 |
| Cy exposure before HSCT (yes vs. no) | 0.50 (0.25–0.99) | 0.046 |
All variables differing between the 2 groups and having a significance level of p < 0.10 in the univariable analysis were first entered into a multivariable Cox regression model, considering relapse and death as competing events. Then, a backward stepwise selection was performed using p < 0.05 and keeping PT-Cy in the model.