Table 1.
Echocardiographic Analyses in the Mouse Chronic Toxicity Model
| Vehicle (n = 10) | IS20 (n = 11) | DOX (n = 13) | DOX + IS20 (n = 17) | |
|---|---|---|---|---|
| Heart rate (beats/min) | 512 ± 19 | 506 ± 22 | 436 ± 11∗ | 457 ± 18∗ |
| LA/BW (mm/g) | 0.08 ± 0.01 | 0.08 ± 0.01 | 0.10 ± 0.02∗ | 0.09 ± 0.02 |
| LVESD (mm) | 2.60 ± 0.44 | 2.73 ± 0.31 | 2.99 ± 0.52 | 2.85 ± 0.4 |
| LVEDD (mm) | 4.19 ± 0.31 | 4.08 ± 0.24 | 4.1 ± 0.46 | 4.18 ± 0.40 |
| LVEDe D/BW (mm/g) | 0.14 ± 0.01 | 0.13 ± 0.01 | 0.18 ± 0.02∗ | 0.18 ± 0.02∗ |
| LV systolic function | ||||
| EF (%) | 75 ± 16 | 71 ± 6 | 65 ± 9∗ | 69.5 ± 3.7 |
| Sa (cm/s) | 2.72 ± 0.8 | 2.33 ± 0.8 | 1.77 ± 0.7∗ | 2.03 ± 0.6∗ |
| Spw (cm/s) | 2.67 ± 0.4 | 2.52 ± 0.4 | 2.08 ± 0.6∗ | 2.16 ± 0.5∗ |
| LV diastolic function | ||||
| E′a (cm/s) | 3.8 ± 1.2 | 3.28 ± 1 | 2.46 ± 0.8∗ | 2.68 ± 1∗† |
| E′pw (cm/s) | 3.5 ± 1 | 3.1 ± 0.7 | 2.3 ± 0.7∗ | 3.0 ± 1 t |
Values are mean ± SD.
BW = body weight; DOX = doxorubicin; E′a = diastolic velocity of mitral annulus; E′pw = diastolic velocity of posterior wall; EF = ejection fraction; IVRT = isovolumic relaxation time; LA = left atrium; LVEDD = left ventricular end-diastolic diameter; LVESD = left ventricular end-systolic diameter; Sa = systolic velocity of mitral annulus; Spw = systolic velocity of posterior wall.
∗
p < 0.05 vs. vehicle.
†
p < 0.05 vs. doxorubicin (DOX).