Central Illustration.

An Approach to Assessment of Cancer Survivors Who Are Pregnant or Contemplating Pregnancy Based on Medical Literature and Current Meta-Analysis

A threshold anthracycline dose to define high risk for pregnancy-related LV dysfunction or HF is unavailable, however, pediatric survivorship guidelines suggest that general screening for cardiomyopathy is reasonable beyond doxorubicin equivalent doses ≥100 mg/m² (25). Thresholds to define younger age and longer time to pregnancy were not available, but the median value for younger age in those who developed LV dysfunction or HF in the studies that reported this as a risk factor were 8.1 years (15) and 14.5 years (17). Similarly, the median value for longer time to pregnancy in the study that reported this variable as a risk factor were 16.9 years (15). CTRCD = cancer-therapeutics related cardiac dysfunction; heart failure = asymptomatic left ventricular systolic dysfunction or clinical heart failure; OR = odds ratio.