Table 3.
Landmark Analysis: Risk of Atrial Fibrillation at 90 Days, 1 Year, and 5 Years After a Cancer Diagnosis
| Noncancer Control Subjects | Cancer Patients | |
|---|---|---|
| 90 days | ||
| Number | 1,631,826 | 813,650 |
| Events | 30,326 | 23,005 |
| Duration, person-years | 8,392,491 | 3,612,754 |
| Time to event, yrs | 3.11 (1.58–4.92) | 1.61 (0.88–3.21) |
| Incidence∗ | 3.61 | 6.37 |
| Model 1: Subdistribution HR (95% CI) | Reference | 1.57 (1.54–1.59) |
| Model 2: Subdistribution HR (95% CI) | Reference | 1.56 (1.54–1.59) |
| 1 yr | ||
| Number | 1,623,932 | 790,183 |
| Events | 26,800 | 18,180 |
| Duration, person-years | 7,165,685 | 3,006,675 |
| Time to event, yrs | 2.74 (1.32–4.40) | 1.25 (0.60–3.08) |
| Incidence∗ | 3.74 | 6.05 |
| Model 1: Subdistribution HR (95% CI) | Reference | 1.45 (1.42–1.48) |
| Model 2: Subdistribution HR (95% CI) | Reference | 1.44 (1.42–1.47) |
| 5 yrs | ||
| Number | 952,163 | 374,557 |
| Events | 8,187 | 2,982 |
| Duration, person-years | 1,802,692 | 683,875 |
| Time to event, yrs | 1.21 (0.56–2.05) | 1.16 (0.53–1.98) |
| Incidence∗ | 4.54 | 4.36 |
| Model 1: Subdistribution HR (95% CI) | Reference | 1.09 (1.04–1.14) |
| Model 2: Subdistribution HR (95% CI) | Reference | 1.08 (1.03–1.12) |
Values are median (interquartile range), unless otherwise indicated. Death was considered a competing risk in Fine and Gray’s competing risk regression model. Model 1: adjusted for age and sex; model 2: adjusted for age, sex, smoking, drinking, regular exercise, socioeconomic status, diabetes mellitus, hypertension, dyslipidemia, body mass index, and chronic kidney disease.
Abbreviations as in Table 2.
∗
Per 1,000 person-years.