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. Author manuscript; available in PMC: 2022 Mar 15.
Published in final edited form as: Int J Radiat Biol. 2021 Mar 15;97(5):664–674. doi: 10.1080/09553002.2021.1876950

Figure 3. Radiation changes the blood flow and vessel structure.

Figure 3.

Five minutes before sacrifice, mice were injected intravenously with 200μl (1mg) of a FITC-labelled dextran/0.9% NaCl solution (2000 kDa). Frozen sections were fixed with 4% paraformaldehyde and images were captured using an Olympus VS120 fluorescence microscope. Analysis of renal perfusion showed that (A-B) non treated (NT) animals displayed a well-perfused honeycomb-like vascular network. This network was disturbed in radiated mice (C-F) and (G) the perfused vessel area was significantly reduced 20 weeks post-RT.