Table 3.

Common Organ Involvement of Systemic AL Amyloidosis With Associated Symptoms/Laboratory Abnormalities

	Signs/Symptoms	Laboratory/Imaging Abnormalities
Heart	Diastolic > systolic dysfunction Arrhythmias (tachy/brady)	Increased wall thickness EKG abnormalities (low voltages, Q waves) Elevated troponin Elevated BNP/NT-proBNP
Kidneys	Edema	Albuminuria/hypoalbuminemia GFR reduction
Gastrointestinal tract	Dysphagia Macroglossia Diarrhea Constipation GI bleeding
Liver	Hepatomegaly	Elevated alkaline phosphatase
Nervous system	Peripheral neuropathy Autonomic dysfunction Carpal tunnel syndrome (especially bilateral)∗
Lungs	Dyspnea	Pleural effusions, pulmonary nodules/infiltrates

AL = light chain; BNP = B-type natriuretic peptide; EKG = electrocardiographic; GFR = glomerular filtration rate; NT-proBNP = N-terminal pro–B-type natriuretic peptide.

^∗Carpal tunnel syndrome commonly occurs from soft tissue deposits within the carpal tunnel space, rather than from direct nerve infiltration.