Table 2.
Clinical Variables According to Anticoagulation Status in Patients With CHA2DS2-VASc Scores ≥2 and HAS-BLED Scores <3: Full Cohort (N = 296)
| Total (N = 296) | No AC (n = 131) | AC (n = 165) | p Value | |
|---|---|---|---|---|
| Age (yrs) | 74.9 ± 8.3 | 73.8 ± 8.8 | 76.2 ± 7.6 | 0.003 |
| Female | 123 (41.6) | 64 (48.9) | 59 (35.8) | 0.020 |
| Hypertension | 194 (65.5) | 74 (56.5) | 120 (72.7) | 0.004 |
| Heart failure | 25 (8.4) | 7 (5.3) | 18 (10.9) | 0.091 |
| Prior atrial fibrillation | 143 (48.3) | 39 (29.8) | 104 (63.0) | <0.001 |
| Diabetes | 81 (27.4) | 34 (26.0) | 47 (28.5) | 0.634 |
| Prior stroke | 29 (9.8) | 10 (7.6) | 19 (11.5) | 0.265 |
| Vascular disease | 61 (20.6) | 25 (19.1) | 36 (21.8) | 0.564 |
| Renal disease | 8 (2.7) | 5 (3.8) | 3 (1.8) | 0.293 |
| Liver disease | 3 (1.0) | 2 (1.5) | 1 (0.6) | 0.433 |
| Prior major bleed | 27 (9.1) | 26 (19.8) | 1 (0.6) | <0.001 |
| Labile INR | 3 (1.0) | 2 (1.5) | 1 (0.6) | 0.476 |
| VTE | 21 (7.1) | 7 (5.3) | 14 (8.5) | 0.404 |
| Chemotherapy, current use | 142 (48.0) | 77 (58.8) | 65 (39.4) | <0.001 |
| Chemotherapy, noncurrent, prior 3 months | 36 (12.2) | 18 (13.7) | 18 (10.9) | 0.592 |
| Perioperative atrial fibrillation | 81 (27.4) | 47 (35.9) | 34 (20.6) | 0.006 |
| NSAID | 34 (11.5) | 20 (15.3) | 14 (8.5) | 0.108 |
| Ibrutinib | 2 (0.7) | 2 (1.5) | 0 (0) | 0.383 |
| Platelet count <50,000/μl | 26 (8.8) | 24 (18.3) | 2 (1.2) | <0.001 |
| Karnofsky score | 80 (70–90) | 80 (70–90) | 90 (70–90) | 0.682 |
| LVEF (%) | 60 (58–63) | 63 (58–63) | 58 (58–63) | 0.512 |
| Brain metastases | 5 (1.7) | 4 (3.1) | 1 (0.6) | 0.246 |
| Cancer type | ||||
| Heme | 65 (22.0) | 45 (34.4) | 20 (12.1) | <0.001 |
| GI | 49 (16.6) | 20 (15.3) | 29 (17.6) | 0.688 |
| Cutaneous | 41 (13.9) | 8 (6.1) | 33 (20.0) | <0.001 |
| GU | 41 (13.9) | 15 (11.5) | 26 (15.8) | 0.357 |
| Lung | 40 (13.5) | 19 (14.5) | 21 (12.7) | 0.805 |
| Breast | 16 (5.4) | 8 (6.1) | 8 (4.8) | 0.841 |
| GYN | 10 (3.4) | 4 (3.1) | 6 (3.6) | 0.783 |
| Sarcoma | 10 (3.4) | 3 (2.3) | 7 (4.2) | 0.541 |
| Other | 25 (8.4) | 10 (7.6) | 15 (9.1) | 0.797 |
Values are mean ± SD, n (%), or median (interquartile range).
Abbreviations as in Table 1.