Study Cohort and CONSORT Diagram
(A) Study cohort: Scatterplot showing the distribution of left ventricular ejection fraction (LVEF) against anthracycline cumulative dose, with control patients in blue (n = 121), case patients in red (n = 238), and the rest in gray (n = 357). (B) Consolidated Standards of Reporting Trials (CONSORT) diagram: selection of case and control patients for exome sequencing in the discovery cohort. ∗Participants with complete data and good-quality DNA. PCS2 = Preventing Cardiac Sequelae in Pediatric Cancer Survivors.