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. 2020 Dec 15;2(5):690–706. doi: 10.1016/j.jaccao.2020.11.004

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Genes Associated With Anthracycline Cardiotoxicity

(A) A total of 28 genes showed differential enrichment between case and control patients by at least 2 methods (p < 0.001), and 3 additional biologically relevant genes (orange) were significant by at least 1 method. (B) Burden of rare and low-frequency single-nucleotide variants in the 31 prioritized genes was higher in control patients compared to case patients (p < 0.001). (C) Forest plot showing the estimated odds ratios (95% confidence intervals) for the 31 top genes in case versus control patients using Fisher exact test. Genes in bold were prioritized for functional studies.

Genes Associated With Anthracycline Cardiotoxicity

(A) A total of 28 genes showed differential enrichment between case and control patients by at least 2 methods (p < 0.001), and 3 additional biologically relevant genes (orange) were significant by at least 1 method. (B) Burden of rare and low-frequency single-nucleotide variants in the 31 prioritized genes was higher in control patients compared to case patients (p < 0.001). (C) Forest plot showing the estimated odds ratios (95% confidence intervals) for the 31 top genes in case versus control patients using Fisher exact test. Genes in bold were prioritized for functional studies.