Figure 3.

Pathways Associated With Anthracycline Cardiotoxicity

(A) GeneMania analysis identified 46 interacting genes, including 26 of the 31 top genes. Large circles represent significantly associated genes; small circles represent other interacting genes. Physical interaction (pink lines), coexpression (purple lines), colocalization (blue lines), shared protein domains (gray-yellow lines), genetic interaction (green lines), and predicted (orange lines). (B) Gene set enrichment analysis identified the top-ranked pathways to which the genes mapped (p < 0.001). The solid bar shows number of significant genes in each pathway (p < 0.001); the dashed bar represents the total genes.