. 2020 Dec 15;2(5):690–706. doi: 10.1016/j.jaccao.2020.11.004

Table 2.

IC₅₀ Values (95% CI) of DOX and Inhibitors in hiPSC-CMs Derived From PGP17 and PGP14 Individuals

	PGP17_11		PGP14_26
	IC₅₀	p Value vs. DOX	IC₅₀	p Value vs. DOX
Doxorubicin	0.09 (0.04–0.16)		0.21 (0.14–0.31)
TGX-221	0.71 (0.51–0.98)	0.045	0.49 (0.33–0.72)	0.043
Metformin	0.58 (0.43–0.78)	0.017	0.98 (0.56–1.80)	0.039
Rapamycin	0.26 (0.14–0.44)	0.178	0.26 (0.17–0.39)	0.164
Dexrazoxane	0.22 (0.15–0.33)	0.077	0.61 (0.43–0.88)	0.047

CI = confidence interval; DOX = doxorubicin; hiPSC-CMs = human induced pluripotent stem cell-derived cardiomyocytes; IC₅₀ = half-maximal inhibitory concentration; PGP = Personal Genome Project.