Table 2.
Multivariable Cox Regression of Potential Risk Factors for LVD40 During Follow-Up
| HR (95% CI) | p Value | |
|---|---|---|
| Model without first EF | ||
| Anthracycline dose (per 100-mg/m2 increment) | 1.71 (1.21–2.40) | 0.002 |
| Chest-directed radiotherapy dose (per 10-Gy increment) | 1.65 (1.20–2.26) | 0.002 |
| Model with continuous first EF | ||
| EF at first echocardiogram (per 10-point decrease) | 9.62 (2.84–32.57) | <0.001 |
| Anthracycline dose (per 100-mg/m2 increment) | 1.43 (1.04–1.98) | 0.026 |
| Chest-directed radiotherapy dose (per 10-Gy increment) | 1.67 (1.21–2.30) | 0.002 |
| Model with categorized first EF | ||
| Midrange versus preserved EF at first echocardiogram | 7.81 (2.07–29.50) | 0.002 |
| Anthracycline dose (per 100-mg/m2 increment) | 1.70 (1.22–2.36) | 0.002 |
| Chest-directed radiotherapy dose (per 10-Gy increment) | 1.91 (1.34–2.72) | <0.001 |
CI = confidence interval; EF = ejection fraction; HR = hazard ratio; LVD40 = left ventricular dysfunction with ejection fraction <40%.