Table 5.

Linear Regression Analysis for Predictors of GLS in Allo-HSCT Survivors (n = 98)

	Univariable			Multivariable
	β	95% CI	p Value	β	95% CI	p Value
Sex	0.38	−0.06 to 0.73	0.092	0.22	−0.16 to 0.59	0.249
Age, yrs∗	−0.06	−0.26 to 0.14	0.548	−0.24	−0.45 to −0.02	0.031
Height, m	0.07	−0.14 to 0.27	0.523
Body mass index, kg/m2	0.01	−0.21 to 0.22	0.964
Heart rate, beats/min	0.33	0.13 to 0.52	0.001	0.34	0.15 to 0.53	0.001
Mediastinal radiation	0.68	−0.74 to 2.10	0.343
Cumulative anthracycline dosage, mg/m2	0.19	−0.01 to 0.39	0.059	0.25	0.07 to 0.44	0.009
Total body irradiation	0.40	−0.44 to 1.24	0.345	0.20	−0.64 to 1.04	0.638
Malignancy	0.38	−0.07 to 0.82	0.095
Hypertension	0.48	0.08 to 0.87	0.019	0.50	0.04 to 0.96	0.035
Diabetes mellitus	0.49	0.93 to 1.91	0.493
Hypercholesterolemia	0.66	0.11 to 1.22	0.020	0.44	−0.14 to 1.02	0.134
Hypothyroidism	−0.37	−1.03 to 0.29	0.271
Smoking, current/previous	0.20	−0.25 to 0.65	0.372
GVHD, acute and/or chronic GVHD	−0.02	−0.44 to 0.39	0.919	−0.29	−0.69 to 0.11	0.158

Linear regression was conducted with standardized continuous variables (including global longitudinal strain [GLS]) and dichotomous variables. GLS is a negative value. Increases in GLS (e.g., with hypertension) reflect worsening in longitudinal shortening (systolic function).

Abbreviations as in Table 4.

^∗Age at examination.