Central Illustration.

Burden of Immune Checkpoint Inhibitor–Associated Cardiovascular Adverse Events

According to the Common Terminology Criteria of Adverse Events (CTCAE) version 5.0, 37.8% of patients receiving immune checkpoint inhibitors (ICIs) developed cardiovascular adverse events. This bar graph depicts the distribution of cardiovascular adverse events, identified by CTCAE, that were adjudicated as major adverse cardiac events. For example, 25 patients on ICI had chest pain by CTCAE, and in 11 patients (44%), these were adjudicated as a major adverse cardiac event. Some patients developed multiple major adverse cardiac events, and each event is counted in this figure. Of note, myopericardial disease includes both pericardial disease and myocarditis.