Table 3.

Mixed Effects Linear Regression Analysis to Estimate the Mean Decline in Percent-predicted Peak Vo₂ for Each Additional Decade Since Radiation Exposure, Adjusting for Potential Confounders

	Least Squares Mean (95% Confidence Interval)	P Value
Model 1: unadjusted
Mean change per 10 yrs	−7.5% (−12.0% to −3.1%)	0.001
Model 2: adjusted for sex
Mean change per 10 yrs	−9.2% (−13.0% to −5.4%)	<0.001
Female	−21.0% (−28.1% to −13.9%)	<0.001
Model 3: adjusted for anthracycline use
Mean change per 10 yrs	−8.7% (−14.3% to −3.1%)	0.002
Anthracycline use	−3.6% (−14.0% to 6.7%)	0.493
Model 4: adjusted for history of hypertension
Mean change per 10 yrs	−7.0% (−11.7% to −2.4%)	0.003
Hypertension	−3.5% (−13.0% to 5.9%)	0.462

The analysis was performed with use of measurements from all cardiopulmonary exercise tests (n = 141).