Figure 1.

FAP CAR T Cells Can Target Cardiac Fibrosis

(A) Schematic of experiments for FAP CAR T cell targeting of cardiac fibroblasts. (B) Picro-Sirius red staining of heart coronal sections in mice treated with saline (left), AngII/PE (center), or AngII/PE and FAP CAR T cells (right) to evaluate fibrosis (red). (Bottom) Magnification of left ventricular fibrosis. Scale bar, 100 μm. (C) Quantification of cardiac fibrosis. ****p < 0.0001; one-way ANOVA between groups, p < 0.0001; Tukey test was used for post-hoc multiple comparisons; n = 10, 9, and 7 biologically independent mice, from left to right. Reproduced with permission from Aghajanian et al. (3). ANGII/PE = angiotensin II and phenylephrine; ANOVA = analysis of variance; CAR = chimeric antigen receptor; FAP = fibroblast activation protein.