Table 2.
Univariate and multivariate logistic regression analysis of variables associated with mortality in the individual patient-level data analysis of 895 patients
|
Univariate analysis |
Multivariate analysis |
|||
|---|---|---|---|---|
| Odds ratio (95% CI) | p value | Odds ratio (95% CI) | p value | |
| Anakinra treatment | 0·38 (0·26–0·56) | <0·0001 | 0·32 (0·20–0·51) | <0·0001 |
| Age >72 years* | 4·97 (3·5–7·06) | <0·0001 | 1·89 (1·12–3·20) | 0·018 |
| Charlson comorbidity index >2* | 6·35 (4·01–10·06) | <0·0001 | 3·75 (1·99–7·07) | <0·0001 |
| PaO2/FiO2 <100 | 2·18 (1·50–3·17) | <0·0001 | 2·89 (1·80–4·64) | <0·0001 |
| CRP >100 mg/L | 1·76 (1·21–2·55) | 0·003 | 1·21 (0·76–1·92) | 0·42 |
| Lymphopenia (<580 lymphocytes per mm3)* | 3·08 (2·12–4·49) | <0·0001 | 3·05 (1·90–4·89) | <0·0001 |
| Study | .. | 0·15 | .. | .. |
CRP=C-reactive protein. PaO2/FiO2=ratio of the arterial partial oxygen pressure divided by the fraction of inspired oxygen.
*
For continuous variables, the best cutoff was estimated from the receiver operating characteristic using the Youden Index.