| Condition1 | Cases (n = 343) |
Controls (n = 686) |
Matched aOR (95% CI)2 |
|---|---|---|---|
| Any underlying condition—n (%) | |||
| < 50 years | |||
| Indicated | 84 (93.3) | 140 (77.8) | 3.71 (1.46, 9.42) |
| Not indicated | 6 (6.7) | 40 (22.2) | Reference |
| ≥ 50 years | |||
| Indicated | 247 (97.6) | 53 (10.5) | 5.05 (2.04, 12.50) |
| Not indicated | 6 (2.37) | 453 (89.5) | Reference |
| Any heart disease3—n (%) | |||
| < 50 years | |||
| Indicated | 51 (56.7) | 62 (34.4) | 2.26 (1.29, 3.95) |
| Not indicated | 39 (43.3) | 118 (65.6) | Reference |
| ≥ 50 years | |||
| Indicated | 208 (82.2) | 354 (70.0) | 2.07 (1.37, 3.13) |
| Not indicated | 45 (17.8) | 152 (30.0) | Reference |
| Obesity—n (%) | |||
| < 50 years | |||
| Indicated | 58 (64.4) | 95 (52.8) | 1.95 (1.10, 3.47) |
| Not indicated | 32 (35.6) | 85 (47.2) | Reference |
| ≥ 50 years | |||
| Indicated | 151 (59.7) | 251 (49.6) | 1.53 (1.11, 2.12) |
| Not indicated | 102 (40.3) | 255 (50.4) | Reference |
| Diabetes—n (%) | |||
| < 50 years | |||
| Indicated | 36 (40.0) | 39 (21.7) | 2.29 (1.27, 4.13) |
| Not indicated | 54 (60.0) | 141 (78.3) | Reference |
| ≥ 50 years | |||
| Indicated | 156 (61.7) | 211 (41.7) | 2.03 (1.46, 2.84) |
| Not indicated | 97 (38.3) | 295 (58.3) | Reference |
| Any lung disease4—n (%) | |||
| < 50 years | |||
| Indicated | 22 (24.4) | 40 (22.2) | 1.06 (0.54, 2.11) |
| Not indicated | 68 (75.6) | 140 (77.8) | Reference |
| ≥ 50 years | |||
| Indicated | 68 (26.9) | 91 (18.0) | 1.73 (1.16, 2.58) |
| Not indicated | 185 (73.1) | 415 (82.0) | Reference |
| Any kidney disease5—n (%) | |||
| < 50 years | |||
| Indicated | 14 (15.6) | 9 (5.0) | 3.05 (1.18, 7.84) |
| Not indicated | 76 (84.4) | 171 (95.0) | Reference |
| ≥ 50 years | |||
| Indicated | 65 (25.7) | 62 (12.3) | 2.38 (1.55, 3.58) |
| Not indicated | 188 (74.3) | 444 (87.7) | Reference |
| Any neurologic/neurodevelopmental condition6—n (%) | |||
| < 50 years | |||
| Indicated | 17 (18.9) | 12 (6.7) | 3.55 (1.40, 8.98) |
| Not indicated | 73 (81.1) | 168 (93.3) | Reference |
| ≥ 50 years | |||
| Indicated | 48 (19.0) | 44 (8.7) | 2.16 (1.33, 3.49) |
| Not indicated | 205 (81.0) | 462 (91.3) | Reference |
| Any mental health diagnosis7—n (%) | |||
| < 50 years | |||
| Indicated | 10 (11.1) | 10 (5.6) | 1.84 (0.69, 4.86) |
| Not indicated | 80 (88.9) | 170 (94.4) | Reference |
| ≥ 50 years | |||
| Indicated | 33 (13.0) | 43 (8.5) | 1.55 (0.92, 2.61) |
| Not indicated | 220 (87.0) | 463 (91.5) | Reference |
| Cancer | |||
| < 50 years | |||
| Indicated | 5 (5.6) | 2 (1.1) | 4.16 (0.74, 23.33) |
| Not indicated | 85 (94.4) | 178 (98.9) | Reference |
| ≥ 50 years | |||
| Indicated | 32 (12.7) | 30 (5.9) | 2.34 (1.36, 4.03) |
| Not indicated | 221 (87.3) | 476 (94.1) | Reference |
1Any condition having a statistically significant aOR with approximately 10% prevalence among case-patients and any not statistically significant aOR of at least 1.5 and at least 15% prevalence among case-patients in unstratified analyses. Because of sparse data when stratifying, specific conditions that were part of grouped categories (e.g., heart disease, lung disease) were not presented on their own. Conditions listed in descending order by overall prevalence among case-patients
2Adjusted for patient sex, marital status, and insurance status. Bold-faced aORs indicate significance at alpha=0.05
3Includes history of heart attack, congestive heart failure, coronary artery disease, hypertension, hyperlipidemia, congenital heart disease, valvular heart disease, and other chronic heart conditions (such as angina, arrhythmias, cardiomyopathy, and pulmonary hypertension)
4Includes asthma, chronic obstructive pulmonary disease, chronic bronchitis, emphysema, cystic fibrosis, and other chronic lung conditions (such as pulmonary nodules, pulmonary fibrosis, and history of pulmonary emboli)
5Includes chronic kidney conditions (such as chronic kidney disease, glomerulonephritis, and polycystic kidney disease)
6Includes conditions such as seizure disorders, intellectual disability, dementia, history of traumatic brain injury, cerebral palsy, and neuropathy
7Includes conditions, such as attention deficit hyperactivity disorder, depression, anxiety, bipolar disorder, schizophrenia, post-traumatic stress disorder, obsessive compulsive disorder, borderline personality disorder, and history of suicidal ideation