Table 1.

Univariate and multivariate cox analyses of prognosis of LUAD patients in the TCGA cohort.

	Univarate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
OS
Gender (male vs female)	0.94 (0.70-1.26)	0.672
Age (>65 vs ≤65)	1.21 (0.90-1.62)	0.212
Stage (III,IV vs I,II)	2.65 (1.95-3.62)	6.50E-10	2.36 (1.71-3.25)	1.89E-07
TLS_signature (high vs low)	0.79 (0.67-0.92)	0.00231	0.72 (0.60-0.87)	0.00049
Smoking_history (Yes vs No)	0.92 (0.61-1.39)	0.682
PFI
Gende r(male vs female)	0.93 (0.71-1.22)	0.605
Age (>65 vs ≤65)	1.09 (0.82-1.43)	0.566
Stage (III,IV vs I,II)	1.623 (1.18-2.23)	0.00284	1.44 (1.03-2.01)	0.03214
TLS_signature (high vs low)	0.84 ( 0.73-0.98)	0.0268	0.74 ( 0.62-0.89)	0.00104
Smoking_history (Yes vs No)	0.97 (0.66-1.45)	0.899