Table 2.

Univariate and multivariate cox analyses of prognosis of LUAD patients in the GSE37745 dataset.

	Univarate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
OS
Gender (male vs female)	0.79 (0.51-1.25)	0.316	0.27 (0.11-0.67)	0.0045
Age (>65 vs ≤65)	1.47 (0.94-2.30)	0.093
Stage (III,IV vs I,II)	1.79 (1.01-3.17)	4.40E-02	6.18 (2.23-17.13)	4.60E-04
TLS_signature (high vs low)	0.59 (0.37-0.94)	0.027	0.46 (0.21-1.01)	0.053
Performance status (≥1 vs 0)	1.61 (1.02-2.53)	0.04	4.0 (1.72-9.32)	0.0013
Adjuvant treatment (yes vs no)	1.14 (0.58-2.27)	0.701
PFI
Gender (male vs female)	0.95 (0.42-2.08)	0.87	0.31 (0.09-1.08)	0.0654
Age (>65 vs ≤65)	0.95 (0.44-2.04)	0.89
Stage (III,IV vs I,II)	1.72 (0.64-4.61)	0.28	2.99 (0.79-11.31)	0.1059
TLS_signature (high vs low)	0.44 (0.20-0.96)	0.0388	0.31 ( 0.11-0.83)	0.0202
Performance status (≥1 vs 0)	1.37 (0.62-3.00)	0.436	2.87 (0.99-8.31)	0.0524
Adjuvant treatment (yes vs no)	1.58 (0.71-3.52)	0.262